Jianru Wang
Personal Information
Name: Jianru Wang
Contact: wangjru@mail.sysu.edu.cn
Address: The First Affiliated Hospital of Sun Yat-sen University No.58, Zhong Shan Er Lu, Guangzhou 510080, P. R. China
Education
Sun yat-sen University, 2008-09 to 2012-06 (Surgery, Ph.D.)
Thomas Jefferson University (USA), 2009-12 to 2011-11 (Surgery)
Zhengzhou University, 2006-09 to 2008-06 (Surgery, Master’s)
Zhengzhou University, 2001-09 to 2006-07 (Clinical Medicine, Bachelor’s)
Research and Academic Experience
Director Physician, First Affiliated Hospital, Sun yat-sen University, 2021-12 to present
Deputy Director Physician, First Affiliated Hospital, Sun yat-sen University, 2017-01 to 2021-12
Attending Physician, First Affiliated Hospital, Sun yat-sen University, 2015-01 to 2016-12
Physician, First Affiliated Hospital, Sun yat-sen University, 2012-07 to 2014-12
Representative Publications
1. Chen Fan, Lei Linchuan, Chen Shunlun, Zhao Zhuoyang, Huang Yuming, Jiang Guowei, Guo Xingyu, Li Zemin, Zheng Zhaomin, Wang Jianru. “Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.” Nature Communications, 2024, 15(1): 47.
2. Wang Xiaolin, Chen Shunlun, Zhao Zhuoyang, Chen Fan, Huang Yuming, Guo Xingyu, Lei Linchuan, Wang Wantao, Luo Yanxin, Yu Huichuan, Wang Jianru. “Genomic G-quadruplex folding triggers a cytokine-mediated inflammatory feedback loop to aggravate inflammatory diseases.” iScience, 2022, 25(11): 105312.
3.Chen Shunlun, Lei Linchuan, Li Zemin, Huang Yuming, Jiang Guowei, Guo Xingyu, Zhao Zhuoyang, Liu Hui, Wang Hua, Liu Caijun, Zheng Zhaomin, Wang Jianru. “Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated phosphorylation of Smad2/3.” Experimental & Molecular Medicine, 2021, 54(4): 518-530.
4.Chen Fan, Liu Hui, Wang Xiaolin, Li Zemin, Zhang Jian, Pei Yuxin, Zheng Zhaomin, Wang Jianru. “Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc.” Osteoarthritis and Cartilage, 2020, 28(8): 1121-1132.
5.Li Zemin, Wang Xiaolin, Pan Hehai, Yang Hao, Li Xiang, Zhang Kuibo, Wang Hua, Zheng Zhaomin, Liu Hui, Wang Jianru. “Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-κB signaling pathways: implications for intervertebral disc degeneration.” Osteoarthritis and Cartilage, 2017, 25(2): 341-350.