Thursday, 30th May 50th International Society for the Study of the Lumbar Spine Annual Meeting 2024

• Relationships between frailty and surgical outcomes of palliative surgery for spinal metastases - Takeru Tsujimoto
• Frailty as a prognostic factor for survival in the elderly patients with spinal metastases: A prospective cohort study - Yutaro Kanda
• AN EVALUATION OF PROGNOSTIC SCORING SYSTEMS FOR SURVIVAL IN A SURGICALLY TREATED COHORT OF 318 PATIENTS - Satyanarayan Naresh Kumar
• Effects of Orthotic Treatment on Fresh Osteoporotic Vertebral Fractures -Propensity Score Matching Test with and without Braces - Masayoshi Iwamae
• The incidence and prognostic factors of delirium in elderly patients with osteoporotic vertebral fractures undergoing kyphoplasty - Tomohiro Nakatani
• Evaluating the Diagnostic Utility of AI Trained on Axial and Coronal CT Scans for Traumatic Thoracolumbar Spinal Fractures - Han-Dong Lee

Schedule

   9:00 - Introduction by ISSLS Prize Committee Chair, Helena Brisby
   9:05 - Presentation 1 (Luca Ambrosio)
   9:15 - Presentation 1 Discussion
   9:20 - Presentation 2 (J Naresh-Babu)
   9:30 - Presentation 2 Discussion

• Superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain - Luca Ambrosio
• How Standing Effects Nutrient Transport in Human Lumbar Discs? - An in-vivo Serial Post-Contrast MRI Study Evaluating Interplay Between Convection and Diffusion. - J Naresh-Babu

Low back pain (LBP) is the largest cause of morbidity worldwide, but the intricate interplay of factors contributing to LBP, spanning genetics, environment, cellular responses, and social and psychological influences, remains incomplete. Unraveling this complexity necessitates a unified, interdisciplinary effort that draws expertise from clinicians, computational scientists, geneticists, cell and molecular biologists, microbiologists, and bioinformaticians.

This symposium features speakers from the EU-funded ITN Project "Disc4All", which applies innovative approaches for integrating computational simulations in both basic science and translational medicine, using intervertebral disc degeneration and LBP as its focus application. The lineup represents the core areas of (a) computer simulation, (b) cell and molecular biology, and (c) genetics within the Disc4All project, ensuring that most members of the diverse audience at ISSLS will find content that resonates with their interests, while also expanding their knowledge through exposure to other facets of this multifaceted research endeavor. We anticipate that this symposium will create a more profound understanding and heightened awareness of:

• Effective strategies for seamlessly integrating computational simulations into translational medicine
• The benefits of incorporating computer models and simulations into intervertebral disc fundamental scientific research.
• The challenges and accomplishments associated with navigating interdisciplinary research
• The transformative potential of ITN projects in shaping the next generation of researchers

Speakers:

Jérôme Noailly, PhD
Universitat Pompeu Fabra
Spain

Benjamin Gantenbein, PhD
University of Bern
Switzerland

Frances Williams, PhD
King’s College London
UK

• SEX-BASED DIFFERENCES IN THE ASSOCIATION BETWEEN CHRONIC LOW BACK PAIN AND BIOMECHANICAL FUNCTION    - Erin S Archibeck
• REFINING GENDER-BASED MUSCULOSKELETAL MODELS: THE IMPACT OF AGE ADJUSTMENT - Nima Ashjaee
• UNVEILING THE INTERACTIONS BETWEEN IVD LOCAL MORPHOLOGIES AND MECHANICAL BEHAVIOR THROUGH A NOVEL MORPHING PROCESS: A STEP TOWARDS PERSONALIZED MEDICINE - Estefano Muñoz-Moya
• DOMINO TOPPLING: WHEN THE DISRUPTION OF ONE DISC NEGATIVELY IMPACTS ITS NEIGHBOUR. AN INVESTIGATION OF ADJACENT SEGMENT DISEASE - Noah Chow
• Recovering In Vivo Intervertebral Disc Geometry, Pressure, and T2 Relaxation Time in Cadaveric Segments - Dawn M Elliott
• A new spine tester "TO GO" and its first ex vivo application abroad - Jan Ulrich Jansen

• The association between physical activity, sitting behaviour and low back pain: Findings from HALO study - Maryam Kazemi
• DIFFERENT LOAD INDUCED BEHAVIOR IN INTERVERTEBRAL DISCS BETWEEN LOW BACK PAIN PATIENTS AND CONTROLS DEMONSTRATED IN A LARGE SCALE T2 MAP STUDY     - Leif LT Torén
• Local temporal variability in physical activity may be more important for episodic pain trajectory classification than patient-reported outcomes and summary measures of activity: implications for objective patient tracking - Karim Khattab
• Effects of sustained locomotion training-based outpatient rehabilitation on the sagittal spinopelvic alignment in locomotive syndrome: a 2-year prospective cohort study - Takashi Yurube
• The impact of exercise prescription variables on intervention outcomes in low back pain disorders: an umbrella review of systematic reviews - Nitin Kumar Arora
• Evaluation of structural alterations and mechanical properties of the lumbar multifidus muscle in chronic low back pain using contemporary images-based methods - Maryse Fortin

Schedule

   2:05 - 2024 ISSLS Wiltse Lifetime Achievement Award recipient announced and presentation
   2:20 - 2023 Basic Science Research Grant award winner presentation (Stefan Dudli) & 2024 recipient announced
   2:25 - 2023 Clinical Science Research Grant award winner presentation (Fabio Galbusera) & 2024 recipient announced
   2:30 - 2023 Clinical Travelling Fellowship award winner presentation (Dr Hong-Jae Lee) & 2024 recipient announced

• Does the quality and the quantity of posterior paraspinal muscles increase the risk of symptomatic intravertebral vacuum cleft sign following vertebral compression fracture at the thoracolumbar junction? - Joonghyun Ahn
• A Novel “Inflammation-Preserving” Treatment for Promoting Lumbar Disc Herniation Resorption in Symptomatic Patients: a Prospective, Multi-Imaging and Clinical Outcomes Study - Hanne Albert
• Sexual dysfunction after primary anterior lumbar interbody fusion in women: a retrospective survey at a high-volume centre - Elena Albertazzi
• Image-based wall shear stresses calculations in cartilage endplate explants and scaffolds in perfusion culture. - Ahmad Alminnawi
• Comparative Efficacy of Endoscopic Unilateral Laminotomy with Bilateral Decompression Versus Interbody Fusion in the Treatment of Grade 1 Lumbar Spondylolisthesis. - Sungjae An
• Efficacy of ¹⁸F-FDG PET-CT for identification of primary lesions in patients with back or radicular pain and spinal metastases of unknown primary origin - Yusuke Aoki
• Prevention for cage retropulsion following posterior lumbar interbody fusion - Hiroyuki Aono
• Impact of spinal instrumentation on early postoperative inflammatory markers: a comparative analysis in the same patient cohort with or without instrumentation - Hiroyuki Aono
• RELIABILITY AND MINIMAL DETECTABLE CHANGE IN VERTEBRAL PELVIC ANGLE MEASUREMENTS IN ADULT SPINAL DEFORMITY - Kasra Araghi
• ULTRASOUND ASSESSMENT OF THE ANTERIOR NECK AND HEMATOMA BEFORE AND AFTER ANTERIOR CERVICAL SPINE SURGERY - Kasra Araghi
• CHANGE IN PROMIS PF AND PI ASSOCIATED WITH CLINICALLY MEANINGFUL IMPROVEMENT IN ODI, BACK PAIN, LEG PAIN, AND PATIENT SATISFACTION AFTER SPINE SURGERY - Kristin R Archer
• Factors associated with improved lumbar spine function after adult spinal deformity surgery - Fumihiro Arizumi
• Efficacy and safety of completely autologous fibrin glue in adult spinal deformity surgery - Fumihiro Arizumi
• The relationship between contrast ratio of bone marrow edema on MRI and exercise prohibition period in lumbar spondylolysis patients - Reo Asai
• Can Muscle Short-Range Stiffness Stabilize the Spine? - Nima Ashjaee
• The Structure of Spine Biomechanics Research - Nima Ashjaee
• The relationship between HRQOL-based recovery trajectories and sagittal balance following surgery for adult spinal deformity - Jeannie F Bailey
• PREVALENCE OF LUMBOSACRAL TRANSITIONAL ANATOMY IN A NEW ZEALAND COHORT – WHOLE SPINE COMPUTED TOMOGRAPHY ANALYSIS - Joe Baker
• THE DELIVERY OF HUMIDIFIED, WARMED AIR TO THE SURGICAL SITE DURING SPINAL SURGERY: FINDINGS FROM A FIRST IN HUMAN CLINICAL TRIAL. - Joe Baker
• Association between MRI measurements of lumbar spine alterations and self-reported outcomes of pain and disability in subjects with non-specific low back pain - Tito Bassani
• PROSEPCTIVE PROPHYLACTIC ANTIBIOTICS REGIMEN IN SCHEDULED SPINE SURGERY - THE PPARISSS COHORT. AN INDEPENDENTLY VERIFIED AND VALIDATED COHORT STUDY OF EXTENDED ANTIBIOTIC PROPHYLAXIS COMBINED WITH STANDARDIZED TISSUE HANDLING AND PERIOPERATIVE WOUND CARE IN 1000 SCHEDULD LUMBAR PEDICLE-SCREW IMPLANT SURGERIES. - Drew A Bednar
• SHOULD THE PELVIS BE INCLUDED? An analysis of Distal Junctional Failure risk factors in correcting Adult Spinal Deformity with fusion to L5 - Pedro Berjano
• IL-4 AND IL-10 ROLE IN HUMAN AND BOVINE INTERVERTEBRAL DISC DEGENERATION  - Paola Bermudez Lekerika
• Ischemic spinal nerve root injury secondary to herniated lumbar intervertebral disc - Paul B Bishop
• Association between skin ultrasound parameters and revision surgery after spinal lumbar fusion - Marco D. Burkhard
• Distinct quantitative sensory testing profiles in female chronic low back pain individuals with and without insomnia - Jeremy Chang
• Conditioned medium of intervertebral disc cells inhibits osteogenesis on autologous bone-marrow-derived mesenchymal stromal cells and osteoblasts - SHUIMU CHEN
• Risk Factors of Revision Operation and Early Revision for Adjacent Segment Degeneration After Lumbar Fusion Surgery: A Case-Control Study - Jae Hwan Cho
• Factors Contributing to Local Recurrence in Metastatic Spinal Cord Compression After Surgery - Jae Hwan Cho
• THE BIOMECHANICAL VIABILITY OF FIXED HUMAN CADAVERS: CAN FIXED CADAVERS OFFER SCIENCE ONE MORE GIFT? - Noah Chow
• The effect of progressive herniation on ovine lumbar functional spinal unit six degree of freedom mechanics - John J Costi
• SENSES AND SURGICAL SUCCESS: EXPLORING SURGEON PERCEPTIONS DURING CORTICAL WALL BREACH AND THE IMPACT OF BREACH ON SCREW PURCHASE - John J. Costi
• Investigation of the combined effects of a catabolic microenvironment and complex mechanical loading on intervertebral disc degeneration - Katherine Crump
• TNF induces catabolism in dynamically loaded human cartilaginous endplate cells in 3D agarose culture - Katherine B Crump
• DIFFERENCES IN DEMOGRAPHIC AND PAIN-RELATED FEATURES BETWEEN NON-SPECIFIC CHRONIC LOW BACK PAIN PATIENTS WITH OR WITHOUT POTENTIAL DISCOGENIC PAIN     - Elisabetta de Rinaldis
• CAN THE PASSIVE STIFFNESS OF HUMAN PARASPINAL MUSCLES BE PREDICTED FROM FIBER BUNDLE CROSS-SECTIONAL AREA AND NUMBER OF FIBERS? - Iraj Dehghan Hamani
• PDGF AB and BB mitigate IVD degeneration through promoting mitogenesis and inhibiting inflammation - Martha Diaz-Hernandez
• RUNX1 PROMOTES INTERVERTEBRAL DISC AGING - Martha Elena Diaz-Hernandez
• ASSOCIATIONS BETWEEN NON-SPINAL COMORBID MEDICAL CONDITIONS AND NEUROPATHIC LOW BACK PAIN - A FURTHER UNRAVELLING OF PAIN COMPLEXITIES IN THE CONTEXT OF LOW BACK PAIN. - Ashish Diwan
• LOW BACK PAIN CLASSIFICATIONS AND THEIR ASSOCIATIONS WITH DISABILITY, QUALITY OF LIFE AND SOCIODEMOGRAPHIC FACTORS - A COMPREHENSIVE EXAMINATION USING THE PAINDETECT QUESTIONNAIRE.  - Ashish Diwan
• Influence of BMI on disability outcomes in Spinal Endoscopic Surgery: a cohort study - Ashish Diwan
• The efficacy of a novel spinous process osteotomy technique in the management of lumbar stenosis with and without degenerative spondylolisthesis - Ashish Diwan
• The utility of clavicle cortex index as a screening tool for low bone mineral density among spine and hip surgery patients. - Yusuke Dodo
• The Effects of Combined Isolated Lumbar Extension Resistance Exercise (ILEX), General Exercise and Manual Therapy versus ILEX Alone on Paraspinal Muscle Morphology and Quality as well as Strength, Pain and Disability in Chronic, Neuropathic and Specific Low Back Pain Patients - Bruno Domokos
• OSTEOPOROSIS COULD BE ASSOCIATED WITH FATTY PSOAS AT UPPER LUMBAR LEVELS: A POSSIBLE MECHANISM UNDERLYING PROXIMAL JUNCTIONAL DISORDERS - Murat Eksi
• How much is physical activity in the early postoperative period after fusion surgery in lumbar degenerative diseases?; An analysis using tri-axis wearable accelerometer - Tatsuya Endo
• PHENOTYPING OPIOID CHRONICITY AND PREDICTING CHANGE IN OPIOID USAGE FROM PHYSICAL THERAPY ELECTRONIC HEALTH RECORDS - Aaron Fields
• Effects of aquatic therapy on paraspinal and gluteal muscle strength and psychological outcomes in individuals with chronic low back pain: Preliminary results - Maryse Fortin
• Correlation of the German Society for Orthopaedics and Trauma (Deutsche Gesellschaft für Orthopädie und Unfallchirurgie) (DGOU) osteoporotic fracture classification with neurological symptoms and surgical interventions for lower lumbar osteoporotic vertebral fractures - KAZUKI KF FUJIMOTO
• Dynamic Non-Fusion Stabilization versus Interbody Fusion for Degenerative Lumber Spondylolisthesis: Minimum 10-Year Follow-Up - Shota Fujimura
• Association between low back pain and fatigue in inhabitants -population-based study in mountain village- - Tatsuhiko Fujiwara
• CLINICAL CHARACTERISTICS OF SLEEP DISTURBANCE IN PATIENTS WITH DEGENERATIVE SPINE DISEASES   - Junichi Yamada
• Expression of Caspase Recruitment Domain-Containing Protein 14 (CARD14) in Human Nucleus Pulposus: Implication for Intervertebral Disc Degeneration - Tatsuhiko Fujiwara
• Postoperative muscle mass changes and clinical outcomes in sarcopenic patients with lumbar degenerative diseases. - SHOTARO FUKADA
• Screw Insertion into Infected Vertebrae in Posterior Fixation for Pyogenic Spondylitis   - Hiroki Fukui
• EFFECTS OF TWO SPINAL MANIPULATIVE THERAPY TECHNIQUES ON SIX DEGREE OF FREEDOM MECHANICAL PROPERTIES OF PORCINE SPINAL SEGMENT MODELS - Martha Funabashi
• Do cells of intervertebral discs with type 1 Modic change on MRI show a history of impaired spinal fusion? - Benjamin Gantenbein
• The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in-vivo rat tail model - Benjamin Gantenbein
• COVID-19 shortened length of stay but worsen mental health of patients after lumbar fusion - Bo Gao
• Interventional procedures for chronic noncancer spine pain: a systematic review and network meta-analysis of randomised trials - Stephane Genevay
• New antibacterial dressings for the treatment of surgical and non-surgical wounds in spine surgery and the treatment of deformity. - Gabriela Graziani
• Antimicrobial functionalization of custom-made vertebral implants by nanostructured metal-based films opposes infection by multi-drug resistant S. aureus - GABRIELA GRAZIANI
• A COMBINED EXERCISE PROGRAMME INVOLVING ASHTANGA YOGA AND AEROBIC EXERCISE IN RUNNERS WITH LOWER BACK PAIN: A RANDOMIZED-CONTROLLED STUDY - Rhiannon RG Green
• A RETROSPECTIVE ANALYSIS OF CORRELATION BETWEEN SAGITTAL ALIGNMENT AND DISTAL JUNCTIONAL FAILURE IN LUMBAR SPINE PATHOLOGY - Cristiana Griffoni
• Risk factors for complications and prolonged length of stay in a single institution retrospective cohort of 336 patients   - Cristiana Griffoni
• An observational study comparing clinical and biomechanical outcome in decompression versus instrumented fusion for lumbar degenerative disease (ARCHIMEDE) - Cristiana CG Griffoni
• POTENTIAL PATHWAYS MEDIATING THE SENOTHERAPEUTIC EFFECT OF O-VANILLIN AND RG-7112 - Lisbet LH Haglund
• Lumbar Spine Coronal Balance Parameters As A Predictor Of The Rehabilitation Management Outcomes In Patients With Radiculopathy Due To Lumbar Disc Herniation: A Multicenter Prospective Cohort Study - Deed E Harrison
• A study on the outcome of lumbar spondylolysis treated with "FRACTURE" imaging without CT - Kenji Hatakeyama
• A Study on the Clinical Features of Interspinous Ligament Lesion in Adolescent Patients with Low Back Pain～Second Report - Kenji Hatakeyama
• Analysis of insertion torque of pedicle screw using penetrating endplate screw technique for L5-S1 interbody fusion. - Masaru Hatano
• Evaluating 1above-1below versus 2above-2below Posterior Fusion Strategies in Thoracolumbar Fractures with Load Sharing Classification Scores ≥7 - Nobuaki Hattori
• THE ACCURACY OF INTUITIVE DIAGNOSIS OF OSTEOPOROSIS USING RADIOGRAPHS AND CTS OF THE LUMBAR SPINE. - Chikara Hayakawa
• FRACTIONS AND CELLULAR INTERACTIONS OF CD16+MONOCYTES AND PLASMACYTOID DENDRITIC CELLS ARE INCREASED IN MODIC TYPE 1 CHANGE BONE MARROW - Irina Heggli
• Vitamin D insufficiency in elderly patients undergoing spinal surgery: a comprehensive evaluation - Hirohito Hirata
• Evaluating the Precision of Percutaneous Pedicle Screw Placement in Lateral Spine Surgery: A Retrospective Analysis of Intraoperative CT Navigation - Akihiko Hiyama
• THE DESIGN OF A SIX-AXIS BIOREACTOR FOR THE APPLICATION OF COMPLEX, DAILY ACTIVITY PROFILES TO WHOLE-ORGAN INTERVERTEBRAL DISC CULTURES - Timothy P Holsgrove
• Single Cell Microgel Encapsulation Promoted MSC Survival and Improved the Therapeutic Efficacy of MSC in Treating Intervertebral Disc Degeneration via Suppressing Pyroptosis - Guanrui Huang
• Effects of decompression surgery on sleep disorders in patients with lumbar spinal stenosis. - Masahiro Inoue
• Relationship Between Paraspinal Muscle Cross-Sectional Area, Fatty Infiltration, and Muscle Strength in Patients with Chronic Low Back Pain - Olivia C Iorio
• Facet Joint Morphology and Tropism in Adolescents: Association with Lumbar Disc Herniation and Spondylolysis - Yoshihiro Ishihama
• Utilizing a Modified Elliptical Tubular Wound Opener in Microscopic Lumbar Decompression Reduces Early Postoperative Pain - Tetsuhiro Ishikawa
• Progression for radiographic lumbar spondylolisthesis in the general population : a 10-year follow-up of the ROAD study - Yuyu Ishimoto
• Serum periostin is associated with disc degeneration - Hayato Ito
• Net Promoter Score in lumbar Surgeries - Hiroki Iwai
• Surgical approach using retrograde transposition of erector spinae by cutting posterior iliac crest for the L5 lesion - Akira Iwata
• Comparison of monobloc and modular cages for different ALIF implantation procedures. An in vitro study - Jan Ulrich Jansen
• USE OF TRANSABDOMINAL MOTOR EVOKED POTENTIAL NEUROPHYSIOLOGICAL MONITORING- A SINGLE INSTITTUTION'S EXPERIENCE - Lakota Jones
• Phenotypic characterisation of the degenerated intervertebral disc: correlating signalling pathway regulation with MRI imaging features. - Aert Scheper
• Short-term outcomes of full-endoscopic disc cleaning surgery for intractable discogenic low back pain with Modic type1 change - Yutaro Kanda
• Sacral deformity associated with adolescent idiopathic scoliosis and appropriate parameters for measuring sacral tilt. - Yuya Kanie
• Association of motivation for home exercise and health-related quality of life in patients with chronic low back pain: a population-based internet survey in Japan - Kinshi Kato
• EVALUATION OF CONSERVATIVE TREATMENT (BRACE) FOR ACUTE OSTEOPOROTIC VERTEBRAL FRACTURE (OVF) ABOUT NON-UNION RATE AND LONG-TERM RESULTS - Tsuyoshi Kato
• Administration of autologous platelet-rich plasma to the intervertebral discs of patients with Modic type 1 changeexperiencing low back pain: A prospective study - Soya Kawabata
• TOMO MAGNETIC RESONANCE ELASTOGRAPHY OF THE LUMBAR SPINE: A PROOF-OF-CONCEPT USING A NOVEL MULTI-FREQUENCY DUAL-ACTUATOR SETUP. - Gregory N Kawchuk
• TRANSCUTANEOUS SPINAL CORD STIMULATION FOR TREATMENT OF CHRONIC LOW BACK PAIN: A PILOT CLINICAL TRIAL - Anastasia Keller
• SENSITIVITY OF SPINAL SEGMENT STIFFNESS TO LOADING CO-ORDINATE SYSTEM POSITION IN FINITE ELEMENT MODELS - Emily S Kelly
• LORDOSIS LOSS IN DEGENERATIVE SPINAL CONDITIONS - Will K M Kieffer
• Comparative Analysis of Extended Endoscopic Lumbar Foraminoplasty (EELF) and Transforaminal Lumbar Interbody Fusion (TLIF): A Preliminary Report from a Prospective Observational Study. - Jun-Hoe Kim
• Aging lumbar intervertebral disc reveals upregulation in immune pathways and activated immune cell populations - MinKyu (Mark) Kim
• Predictors of Complications and Unfavorable Outcomes of MIS Treatment in Elderly Patients with Degenerative Lumbar Spine Pathologies - Vladimir Klimov
• Clinical results of intervertebral disc enzyme injection therapy for lumbar disc herniation in 100 consecutive patients at our institution. - Atsushi Kojima
• Spinopelvic Alignment-Driven Etiology of Endplate Abnormalities of the Lumbar Spine in Humans - Takuhei Kozaki
• Semisupervised Spinal Tumor Segmentation Based on Three-Dimensional Topological Constraints and Uncertainty Analysis - Xihe Kuang
• NiTinol shape memory smart implants for orthopedics: A Review of Precision 3D Printing, Biocompatibility, Potential Clinical and Surgical applications - Satyanarayan Naresh Kumar
• CAN A DEEP LEARNING ARTIFICIAL INTELLIGENCE MODEL LEAD TO EARLIER DIAGNOSIS OF HIGH GRADE METASTATIC EPIDURAL SPINAL CORD COMPRESSION AND REDUCTION IN TREATMENT DELAY? - Satyanarayan Naresh Kumar
• Agonist-induced activation of Transient Receptor Potential Vanilloid 4 promotes autophagy and extracellular matrix synthesis through AMPK pathway in rat intervertebral disc - Kohei Kuroshima
• Is metabolic syndrome related to sarcopenia? Analysis of correlation between 3D volumetric measurements of abdominal muscles and fat using abdominal CT scan based AI deep learning algorithm for 980 health checkup patients. - Ji-Won Kwon
• Employing native instructive stimuli and epigenetic memory to stimulate iPSC differentiation towards notochordal-like cells - Lisanne T Laagland
• Notochordal cell matrix-based hydrogel promotes the healthy phenotype and matrix production of intervertebral disc cells - Lisanne T Laagland
• Detailed characterization of vertebrae in 69 healthy adolescents using objective MRI markers – a cross sectional study - Kerstin Lagerstrand
• In vivo evaluation of the intradiscal deformation and its relation to annular fissuring in the lumbar spine - Kerstin Lagerstrand
• Elastin degradation products accelerate chondrogenesis and calcification of human ligamentum flavum-derived cells - Wing Moon Raymond Lam
• Increased matrix metalloproteinase-2 in ligamentum flavum hypertrophy and the regulation of MMP-2/TIMPs by elastin-derived peptides - Wing Moon Raymond Lam
• X-ray scattering imaging of intervertebral discs under load - Christine L Le Maitre
• The incidence and risk factors of wound revision following surgical treatment for spinal metastasis :a national population-based study in South Korea - Han-Dong Lee
• Exploring the Impact of Mild-to-Moderate Foraminal Stenosis at L5−S1 on Clinical Outcomes Following L4−5 Lumbar Interbody Fusion - Hyung Rae HR Lee
• Effect of Lumbar Spinal Stenosis on Treatment of Osteoporosis: Comparison of Three Oral Bisphosphonate Therapies - Jun-Seok Lee
• Risk factors for proximal junctional kyphosis in adult spinal deformity patients with concurrent osteoporosis undergoing long-segment spinal fusion surgery. - Zhangfu Li
• The role of lumbosacral paraspinal muscle degeneration and low vertebral bone mineral density on distal instrumentation-related problems following long-instrumented spinal fusion for degenerative lumbar scoliosis: a retrospective cohort study - Zhangfu Li
•  COL10A1 MUTATIONS LEAD TO EARLY-ONSET LUMBAR VERTEBRAL ENDPLATE DEFECTS AND DISC DEGENERATION IN HUMAN AND MICE - Jiachen Lin
• Predictors of sciatica from early adulthood to midlife – a 15-year follow-up study - Juhani Määttä
• Lumbosacral transitional anatomy alters the mobility of the lumbar spine on flexion-extension radiographs - Juhani Määttä
• Graded activity for chronic low back pain - a Cochrane systematic review - Lisandra LA Almeida
• Can the physiotherapist successfully identify “yellow flags” in patients with spinal disorders? - Francine Mariaux
• Unstable pseudoarthrosis causes residual low back pain following conservative treatment of osteoporotic vertebral fractures - Masaru Hatano
• Evaluation of bone quality in patients with adult spinal deformity using intraoperative Pedicle Screw Insertional Torque: A Comparative Analysis with Bone Mineral Density, Vertebral Bone Quality Score and CT Hounsfield units - Keishi Maruo
• Perioperative issues in spinal surgery for patients undergoing treatment for psychiatric disorders - Kazuhiro Masuda
•  Effects of concomitant decompression adjacent to a posterior lumbar interbody fusion segment on clinical and radiologic outcomes: Comparative analysis 5 years after surgery - Tomiya TM Matsumoto
• Transient Receptor Potential Vanilloid 4 (TRPV4) knockdown decreases matrix synthesis by diminishing autophagy in rat intervertebral disc - Tomoya Matsuo
• Investigation of positive Scottie dog sign and the cleft distance at terminal stage of lumbar spondylolysis. - Satoshi Matsuura
• Lumbar spine T2-weighted MRI radiomics successfully classify intervertebral disc degeneration in the Northern Finland Birth Cohort 1966 - Terence P McSweeney
• MIND YOUR PAIN: MIXED-METHODS ASSESSMENT OF A SMARTPHONE-BASED INTEROCEPTIVE ATTENTION TRAINING FOR MANAGING CHRONIC LOW BACK PAIN - Wolf E Mehling
• HYDROGEL INJECTION AND MECHANICALLY INTERLOCKING PATCH PARTIALLY RECOVER INTERVERTEBRAL DISC MECHANICS WHILE WITHSTANDING PHYSIOLOGICAL LOAD - Danilo Menghini
• Intervertebral Disc Microbiome in Modic Changes: lack of result replication underscores the need for a consensus in low-biomass microbiome analysis - Tamara Mengis
• COMPARISON OF PRIMARY VERSUS REVISION BIPORTAL ENDOSCOPIC INTERBODY FUSION  - Alex Miller
• A COMPARISON OF TWO CAGE SIZES IN BIPORTAL ENDOSCOPIC TRANSFORAMINAL LUMBAR INTERBODY FUSION  - Alex Miller
• Responsiveness of Zurich Claudication Questionnaire in patients with lumbar spinal stenosis undergoing nonsurgical treatment: a secondary analysis of a randomized controlled trial - Masakazu Minetama
• Minimal clinically important differences in walking capacity and physical activity for patients with lumbar spinal stenosis undergoing nonsurgical treatment: a secondary analysis of a randomized controlled trial - Masakazu Minetama
• Lumbar pedicle stress fracture by the disruption of neural arch continuity: Two cases of post-laminotomy and bilateral spondylolysis - Tetsuryu Mitsuyama
• Evaluation of Dynamic Spinal Alignment Changes and Compensation Using Three-dimensional Gait Analysis Synchronized with Electromyography for Adult Spinal Deformity - Kousei Miura
• The prevalence and characteristics of Sarcopenia, pre-Sarcopenia, and Dynapenia in patients with osteoporosis - Masayuki Miyagi
• Minimally invasive decompression alone for lumbar spinal stenosis with degenerative spondylolisthesis: A prospective study to clarify the advantages and disadvantages - Akira Miyauchi
• Chondroitin sulfate proteoglycan administration has therapeutic potential for disc degeneration by stimulating anabolic turnover of bovine nucleus pulposus cells - Kunihiko Miyazaki
• EXTRACTED NATIVE CHONDROITIN SULFATE PROTEOGLYCAN STIMULATES ANABOLIC TURNOVER IN BOVINE NUCLEUS PULPOSUS CELLS UNDER PHYSIOLOGICALLY RELEVANT CULTURE CONDITIONS IN VITRO - Kunihiko Miyazaki
• Early identification of patients with potential for advanced thoracolumbar/lumbar curve progression - Masaya Mizutani
• When will spine surgeons in Orthopaedics and Neurosurgery in Japan finally achieve the gender diversity goal? - Tadatsugu TM Morimoto
• Can Surgical Apgar Score (SAS) predict postoperative complications in PLIFs with single-level? - Sho Muguruma
• Progression of lumbar disc degeneration: a 14-year follow-up study with a detailed examination of variables in Pfirrmann classification - Niko Murto
• IMPACT OF SURGICAL TREATMENT ON LIPID METABOLISM IN PATIENTS WITH LUMBAR SPINAL DISORDERS: PROSPECTIVE OBSERVATIONAL STUDY   - Sota Nagai
• Preoverative pelvic incidence minus lumbar lordosis mismatch in repeat posterior lumbar interbody fusion induces subsequent corrective long fusion - Yukitaka Nagamoto
• Comparative study of the nonsurgical treatment for Osteoporotic Fracture Treatment Score (OF-score) high group and low group. - Kazuma Nagao
• Assessment of cage placement in transforaminal lumbar interbody fusion (TLIF) using 3D porous boomerang-shaped titanium alloy cages. - Takane Nakagawa
• Diagnostic identification of intradural extramedullary spinal tumor on quantitative MRI - Toshio Nakamae
• A COMPARATIVE CLINICAL STUDY OF LATERAL LUMBAR INTERBODY FUSION BETWEEN IN MOB PATIENTS AND IN FIRST-TIME SURGERY PATIENTS - Masato Nakano
• Can Pre-Operative Traction Imaging Predict the Success of Indirect Decompression? - Results of A Novel Pre-Operative MR Imaging Study In Traction & Weight Bearing. - J Naresh-Babu
• OSTEOPOROSIS MICE FOLLOWING OVARIECTOMY EXHIBIT BEHAVIOURAL INDICATORS OF OSTEOPOROSIS-RELATED PAIN AND PAIN-RELATED SENSORY INNERVATION IN LUMBAR VERTEBRAE - Miyako NARITA
• Internal strain and stress distributions in human lumbar vertebra: investigating the effect of disc degeneration using digital volume correlation - Nicolas Newell
• The burden of back pain translates to some, but not all, family members – the first ever exploration of family-reported outcome measurements in back pain. - Casper Nim
• ANTICIPATION OF COMPLEX DYNAMICS AMONG PROTEASES, TIMP AND PRO-INFLAMMATORY CYTOKINES WITHIN THE NUCLEUS PULPOSUS - A GRAPH-BASED MODELING APPROACH - Jerome Noailly
• Postural control in adult spinal deformity: A systematic review of the literature       - Paul A Oakley
• Comparison of surgical outcomes in metastatic spine tumors according to the grade of the primary site - Hiroki Ohnishi
• RELATIONSHIP OF DISCOGRAPHY TO RE-OPERATION FOR DISC-RELATED PAIN MORE THAN 10 YEARS AFTER LUMBAR TOTAL DISC REPLACEMENT   - Donna D Ohnmeiss
• Methods for the evaluation of the lumbar intervertebral disc vacuum phenomenon to predict postoperative residual lower back pain - SHUHEI OHYAMA
• Clinical outcomes and risk factors associated with spinal kyphotic deformity following osteoporotic vertebral fracture.   Loss of lower lumbar lordosis cause spinal kyphotic deformity and affect activities of daily living after osteoporotic vertebral fracture. - Hayato H.O Oishi
• Trans Iliac Rod Fixation (TIRF) through a posterior approach for fragility fracture of pelvis, one of the causes of low back pain in the elderly, enables early bed release and  shorter hospital stay. - Yasuaki Okada
• COMPARISON OF TRUNK MUSCLE ACTIVITY DURING SIT-TO-STAND MOVEMENT AT DIFFERENT SEAT HEIGHTS - Yu Okubo
• Utility of MR Bone Imaging in the Diagnosis of Pediatric Lumbar Spondylolysis: A Potential Substitute for CT - Kohei K Okuyama
• CHRONIC LOW BACK PAIN MECHANISTIC PHENOTYPES: PREVALENCE IN THE BACKHOME COHORT - Conor ONeill
• EFFECT OF STAT3 SIGNALLING PATHWAY MODULATOR ON SENESCENCE OF NUCLEUS PULPOSUS CELLS   - Jolita Pachaleva
• Application of Escherichia coli-derived Recombinant Human Bone Morphogenic Protein-2 to Unstable Spinal Fractures - Hyung-youl Park
• Changes and affecting factors of sagittal alignment after decompressive laminectomy for lumbar spinal stenosis: Analysis using the EOS imaging system - Hyung-youl Park
• Cross-country skiers who suffer from low back pain have more disc degeneration than their asymptomatic peers - Janne Pesonen
• LUMBOPELVIC MOTOR CONTROL AND MUSCLE ACTIVITY DURING CLINICALLY ADAPTED TESTS: TEST-RETEST RELIABILITY - John M Popovich, Jr.
• STRATIFYING LOW BACK PAIN PATIENTS IN AN INTERPROFESSIONAL EDUCATION AND SELF-MANAGEMENT MODEL OF CARE: RESULTS OF A LATENT CLASS ANALYSIS - Y. Raja Rampersaud
• A comparison of surgical outcome and equitable access for hip, knee and lumbar spine surgery for endstage osteoarthritis - Y. Raja Rampersaud
• Applications and Limitations of Forward Dynamic Active Hybrid Spine Models with a Muscle-Driven Approach - Robin Remus
• Functional Disability and Work Ability in Workers affected by Low Back Pain: An Innovative Multidisciplinary Approach - Fabrizio Russo
• The Importance of Psoas Muscle on Low Back Pain: a Single-Center Study on Lumbar Spine MRI - Fabrizio Russo
• Development of gene-silencing therapies for intervertebral disc cells based on the functional analysis of intracellular mTOR signaling using RNA interference and CRISPR–Cas9 - Masao Ryu
• Anterior spinal fusion for Lenke 5C adolescent idiopathic scoliosis: Can the S-line predict postoperative proximal decompensation? - Yota Sakuma
• Exploring a Novel Spheroid 3D Cell Culture System for Tie2⁺ Nucleus Pulposus Cells of the Intervertebral Disc - Leon Schlagenhof
• Relationship between types of warming devices and surgical site infection in patients who underwent posterior fusion surgery based on national data - SANGYUN Dr SEOK
• Settling-down of Fusion Construct after Deformity correction for Degenerative Sagittal Imbalance - SANGYUN Dr SEOK
• Extra-segmental Influence of Lower Lumbar Disc Degeneration on Development of Osteoporotic Vertebral Fractures at Thoraco-Lumbar Junction. - Aseem Sharma
•  Extracellular vesicles derived from myofibroblasts leverages a bio-integrated polymer gel for annulus fibrosus repair - Yue Wang
• Analysis of the lumbar spine curve of adolescent idiopathic scoliosis Lenke type 1 and 5 using a 3-dimensional polygonal model. - Yuichi Shimizu
• DISTAL LORDOTIC ANGLE INDEPENDENT OF PELVIC INCIDENCE TO REDUCE THE RISK OF ADJACENT SEGMENT DEGENERATION FOLLOWING IN L4-S1 POSTERIOR LUMBAR INTERBODY FUSION     - Myung-Hoon Shin
• SAGITTAL SPINAL SHAPE EVOLUTION IN THE DEVELOPMENT OF THORACIC OSSIFICATION OF THE LIGAMENTUM FLAVUM   - Myung-Hoon Shin
• MECHANICAL AGE-RELATED DIFFERENCES IN THE HUMAN CADAVERIC ANNULUS FIBROSUS - Sabrina I Sinopoli
• PCRX-201, a novel gene therapy treatment approach for intervertebral disc degeneration - Joseph Snuggs
• Mechanistic Analysis of the Effect of Laminin 511 on the Proliferation of Cultured Human Nucleus Cells - Hazuki H.S Soma
• MULTIFIDUS MUSCLE ADAPTIONS AFTER 16 WEEKS OF HEAVY LOADED SPECIFIC EXERCISE PROGRAM IN PATIENTS WITH CHRONIC LOW BACK PAIN AND HERNIATED DISCS – A PROSPECTIVE MRI STUDY - Christoph Spang
• A COMPARATIVE ANALYSIS OF TIE2-POSITIVE IVD PROGENITOR CELLS IN SINGLE-CELL AND BULK TRANSCRIPTOMICS - Anja Stirnimann
• Mini-OPEN ANTERIOR LUMBAR INTERBODY FUSION (mini-ALIF) FOR DEGENERATIVE SPONDYLOLISTHESIS - Sho Muguruma
• Insight into Association Between Vertebral Endplate Defects and Patient-reported Symptoms: An Immunohistochemical Study on the COX-2/PGE-2/EP-4 Axis - Xu Sun
• Supradjacent Disc Herniation in L5/S1 Low-grade Isthmic Spondylolisthesis: Incidence and Risk Factors - Xu Sun
• Investigation of bone healing rate with three types of braces for elementary children with lumbar spondylolysis - Noritaka Suzuki
• The fusion rate of lumbar spondylolysis in junior and senior high school students: Treatment with a semi-rigid brace for unilateral cases - Noritaka Suzuki
• The predictive psychosocial factors to improve the degrees of pain evaluated before multidisciplinary pain treatment for chronic musculoskeletal pain, including low back pain - Naoto Takahashi
• Variations in thoracolumbar sagittal alignment in elderly population based on healthy volunteers cohort study - Shinji Takahashi
• Characteristics and comparative study of thoracolumbar spine injury and dislocation fracture due to tertiary trauma - Hiromitsu Takaoka
• Percutaneous Pedicle Screw Is a Risk Factor of Early Pedicle Screw Pull-out After Posterior Instrumentation Surgery - Taishi Takeuchi
• SOD2 Modulates Intervertebral Disc Degeneration during Aging - Shota Tamagawa
• Comparison of body composition and intervertebral disc degeneration in patients with lumbar degenerative spine disease and healthy adults - Masaru Tanaka
• Characteristics of and treatment for residual neuropathic pain after lumbar spine surgery  - Yoshihide Tanaka
• Factors inhibiting union in lumbar spondylolysis with contralateral pseudarthrosis - Masaki Tatsumura
• LOW-MAGNITUDE HIGH-FREQUENCY VIBRATION INCREASES CELLULARITY AND PRODUCTION OF CATABOLIC FACTORS IN A SIMULATED DEGENERATIVE BOVINE INTERVERTEBRAL DISC MODEL - Graciosa Q Teixeira
• Intradiscal pressure during low-magnitude-high-frequency vibration in a bovine disc degeneration model - Graciosa Quelhas Teixeira
• Microscope-based augmented reality navigation for spinal cord tumor resection - Fumitake FT Tezuka
• Microscope-based augmented reality navigated pedicle screw insertion for thoracolumbar spine diseases - Fumitake FT Tezuka
• LUMBOPELVIC ALIGNMENT IN PATIENTS WITH LUMBAR SPINAL STENOSIS AND MODIC TYPE 1 VERTEBRAL ENDPLATE CHANGE - Naoka Tomiya
• UNIQUE GUT MICROBIOME SIGNATURE ASSOCIATED WITH PAIN AND DISABILITY IN A CLBP POPULATION: AN EXPLORATORY ANALYSIS. - Valerio Tonelli Enrico
• Predictors of poor patient satisfaction following lumbar microendoscopic laminectomy - Keiichiro Tozawa
• Short-term results of thermal‑sprayed silver‑containing hydroxyapatite‑coated cage for lumber interbody fusion - Masatsugu Tsukamoto
• Relationship between diffuse idiopathic skeletal hyperostosis and physical function in the general elderly population - Masashi Uehara
• Investigation on the pathogenesis of spinal deformity using a mouse model of musculocontractural Ehlers-Danlos syndrome - Masashi Uehara
• Are AI-based Large Language Models valid tools for patient information on lumbar disc herniation? The spine surgeons' perspective - Jacopo JV Vitale
• BENEFICIAL THERAPEUTICS EFFECTS ON INTERVERTEBRAL DISCS OF AGING MALE MICE TREATED WITH THE SENOLYTIC BCL-XL/BCL-2 PROTAC DEGRADER 753B - Nam Vo
• Epigenetic Regulation of Collagen I Expression By Histone Lactylation in Annulus Fibrosis Cells - Nam Vo
• Social Determinants of Health Associated with Lower Patient-Reported Outcomes in Lumbar Spine Patients - Aboubacar Wague
• Impact of Depression on Patient-Reported Outcome Measures After Lumbar Spine Surgery - Aboubacar Wague
• The KAZALD1 promoter g-quadruplex: an epigenetic switch triggering cellular senescence and intervertebral disc degeneration - Jianru Wang
• Postoperative low back pain and related life quality in patients with lumbar disc herniation: A 1-year follow-up study of 538 cases after percutaneous endoscopic lumbar discectomy - Ming Guan
• Lumbar disc herniation in juveniles: A case–control study of MRI characteristics and etiological insights - Ming Guan
• Sagittal imbalance relates to the development of dementia in local community residents: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study (LOHAS)   - Kazuyuki Watanabe
• Influence of surgical mobilization strategies in adolescent idiopathic scoliosis on the range of motion - Hans-Joachim Wilke
• POTENTIAL CAUSAL ASSOCIATION BETWEEN HUMAN CYTOMEGALOVIRUS INFECTION AND CHRONIC BACK PAIN: A ONE-SAMPLE MENDELIAN RANDOMISATION STUDY - Frances MK Williams
• The effect of transcutaneous electrotherapies on self-reported outcomes in chronic low back pain patients: a systematic review and meta-analysis - Daniel Wolfe
• Do corrective spine surgeries improve gait parameters in teenagers with adolescent idiopathic scoliosis? A systematic review and meta-analysis - Arnold Wong
• HOW MEASURING SPINO-PELVIC PARAMETERS IN HIP-SPINE SYNDROME INFLUENCES SHARED SURGICAL DECISION MAKING FOR BOTH THE HIP AND SPINE SURGEON - David Wong
• The Role of miR-155 in Inflammation and Mechanosensing of Intervertebral Disc Cells - Karin Wuertz
• Periostin increased by mechanical stress upregulates interleukin-6 expression in the ligamentum flavum - Akito Yabu
• RETROSPECTIVE ANALYSIS OF LUMBAR MRI PHENOTYPE OF DEGENERATED DISCS IN PATIENTS WITH DISCOGENIC LOW BACK PAIN FOLLOWING INTRADISCAL PLATELET-RICH PLASMA RELEASATE TREATMENT - Junichi Yamada
• Trends in the surgical treatment for metastatic spinal tumor in Japanese administrative data between 2012 and 2020. - Kentaro Yamada
• Less-Invasive Decompression Procedures Can Reduce Risk of Reoperation for Lumbar Spinal Stenosis With Diffuse Idiopathic Skeletal Hyperostosis Extended to the Lumbar Segment: Analysis of Two Retrospective Cohorts - Kentaro Yamada
• Predictive Factors for Stroke during Hospitalization in Spinal Disease: A Case Series Study and Meta-Analysis - Katsuki Yamaguchi
• The Efficacy of a TGF-β Inhibitor on the Biomechanical and Histological Properties of Paraspinal Muscles after Posterior Lumbar Spinal Surgery in a Rat Model - Shun Yamamoto
• Accuracy of pedicle screw placement with three different guided technique in adolescent idiopathic scoliosis: Retrospective study of 1385 screws - Kazuta Yamashita
• Radiation exposure due to CT navigated technique in adolescent idiopathic scoliosis - Kazuta Yamashita
• EARLY EXPERIENCES WITH INJECTABLE MAGNESIUM-BASED BONE VOID FILLERS FOR SPINAL INSTRUMENTATION: A SINGLE CENTRE REVIEW - Cassie Yang
• Clinical significance of redundant nerve roots in patients with lumbar spinal stenosis. -A retrospective single center study using patient-based outcomes- - Kodai Yoshida
• Current Knowledge on the Different Characteristics of Back Pain in Adults with and without Scoliosis: A Systematic Review - Fabio Zaina
• Can currently used questionnaires like ODI (and SRS-22) discriminate patients with scoliosis in a population with chronic back pain?   - Fabio Zaina
• SpineGPM: A generative pretrained model for 3D spine synthesis based on back geometry with single-centre clinical validation on scoliosis diagnosis - Ashish Diwan
• Generation of Lateral Radiograph-Comparable Images for Spine Alignment Assessment - Ashish Diwan
• RISK PREDICTION OF EARLY MORTALITY AFTER SPINAL METASTASIS SURGERY WITH PREOPERATIVE LABORATORY DATA AND MAJOR ORGAN METASTASIS - Zhongying Zhang
• Are changes in pain intensity related to changes in balance control in individuals with non-specific chronic low back pain: a systematic review and meta-analysis - Daniel KY Zheng
• mHealth apps for the self-management of low back pain: an analysis of content, quality and approaches used   - Tianyu Zhou
• Aspin: Neurosurgical Aspirin Intervention Prognostic Study; a randomized non-inferiority trial. - Ahmed Zian
• Presence of magnetic resonance imaging proxies (MRIPs) for segmental instability is associated with increased leg pain at five-year follow-up after decompression surgery for spinal stenosis without spondylolisthesis - Oliver Zielinski
• The reliability and validity of clinical ultrasound in assessing the adolescents with idiopathic scoliosis (IS) at different body mass indexes (BMIs) - Yi Ying Zou
• Cumulative incidence for radiographic lumbar sponylolisthesis in the general population : a 10-year follow-up of the ROAD study - Satoshi Arita

• TRPC6 regulates inflammation and catabolism in intervertebral disc degeneration - Janitri Venkatachala Babu
• A population-based cohort longitudinal study identified genetic effects of intervertebral disc degeneration progression - Tsuyoshi Deguchi
• The T1ρ Z-score: a novel method for quantifying age-relative disc degeneration - Noah B Bonnheim
• Coexistence of vertebral and intervertebral disc changes in low back pain patients – in depth characterization with same day MRI and CT discography - Kerstin Lagerstrand
• Prevalence and distribution of Schmorl node and endplate signal change, and correlation with disc degeneration in a population-based cohort: The Wakayama Spine Study - Masatoshi Teraguchi
• CHRONIC ALCOHOL CONSUMPTION CAUSES DEGENERATIVE CHANGES IN SPINAL STRUCTURES - Svenja Illien-Junger

This focus group aims to report on the update of the biomarker expert opinion project, review recommendations for the development and use of low back pain biomarkers to phenotype patients and improve treatment outcomes, and to help map available population-/patient-based cohorts of degeneration/back pain for worldwide collaboration.

Speakers:

Michael J. Schneider, DC, PhD
Dept. of Physical Therapy
University of Pittsburgh

James E. Eubanks, MD, DC, MS
Medical University of South Carolina (MUSC), Dept. of Orthopaedics,
Division of Physical Medicine and Rehabilitation;
University of Pittsburgh Medical Center (UPMC), Dept. of Physical Medicine and Rehabilitation

Rob JEM Smeets, MD, PhD
Dept. of Rehabilitation Medicine, Maastricht University and CIR Revalidatie
Eindhoven, The Netherlands;
Pain in Motion International Research Group

Held at the Museo della Scienza e della Tecnica, this must attend social dinner will be a sought after function. Transfers and a guided tour of the museum are included.