Tuesday, 28th May 50th International Society for the Study of the Lumbar Spine Annual Meeting 2024

07:45 - Welcome by the Local Hosts

07:55 - Program Chair Report: Dawn Elliott

Following each group of three speakers, there will be a 15-minute discussion in this session.

• DESCRIBING AVAILABLE PREOPERATIVE EDUCATION METHODS AND COMPARING OUTCOMES FOR SPINAL FUSION CANDIDATES: A CROSS-CANADA STUDY     - Eden A Richardson
• Preoperative sleep disturbance and depression, in isolation and combined, are predictors of 12-month disability and pain after lumbar spine surgery - Rogelio A Coronado
• Association between new occurrence of Modic changes and low back pain: 11-year follow-up Minami Aizu Study - Kenji Kobayashi
• The association of hip muscle strength and asymmetry with functional performance and disability in individuals with chronic low back pain - Sara R Piva
• LUMBAR PARASPINAL MUSCLES EPIMUSCULAR FAT IS ASSOCIATED WITH INTRAMUSCULAR FAT INFILTRATION, BMI AND LOW BACK PAIN IN PATIENTS WITH BACK DISORDERS. - Jacopo Vitale
• An AI-based approach for automated paraspinal muscle analysis and disc identification in patients affected by low back pain  - Fabrizio Russo

Following each group of three speakers, there will be a 15-minute discussion in this session.

• ALTERATIONS IN NUCLEUS PULPOSUS OXYGEN, GLUCOSE AND LACTATE CONCENTRATIONS IN A PRECLINICAL GOAT MODEL OF DISC DEGENERATION - Lachlan J Smith
• SHH and TBXT as target biomolecules to regenerate intervertebral disc tissue: lessons learned from extracellular vesicles  - C. Voskamp
• Differentiation of hiPSCs into notochordal cells identifies the role of histone lysine demethylase (KDMs) as a regulator of notochordal differentiation. - Martha Elena Diaz Hernandez
• Investigating the Effects of Stiffness and Topography on TRPV4 Activation in AF Mechanotransduction - Mikkael Lamoca
• Selective RNA interference of RAPTOR/mTORC1 effectively alleviates degenerative disc disruption and also improve degenerated disc microenvironment in a rat tail temporary static compression model - Naotoshi Kumagai
• SINGLE-CELL UNDERSTANDING OF INTERVERTEBRAL DISC DEGENERATION YIELDS NEW TREATMENT STRATEGIES - Marianna A Tryfonidou

Following each group of three speakers, there will be a 15-minute discussion in this session.

• EARLY LUMBAR INTERVENTION AFTER PRESENTATION TO THE EMERGENCY SETTING: A COMPARISON OF POST-OPERATIVE OUTCOMES.      - Alex K Miller
• Assessing the Association of Post-operative Patient Portal Messaging With Hospital Readmission After Lumbar Spine Surgery - Theresa L Chua
• Latent Facet Joint Cyst after Lumbar Decompression Surgery: Its Impact on Postoperative Outcomes and Its Course - Takahiro Tsutsumimoto
•   The Impact of Prior Arthroplasty on the Oswestry Disability Index and Patient Satisfaction Two Years after Lumbar Surgery - Paul Köhli
• OUTCOME PREDICTION FOLLOWING LUMBAR DISC SURGERY (OPtiDisc): A LONGITUDINAL STUDY OF OUTCOME TRAJECTORIES, PROGNOSTIC FACTORS, AND RISK MODELS.    - Erin Bigney
• WHAT HAPPENED TO PATIENTS WHO RECEIVED THE CHARITE LUMBAR ARTIFICIAL DISC? - Donna D Ohnmeiss

Low-back pain is the world’s most disabling condition, with tremendous amount of socioeconomic consequences. Depending on cause and severity, back pain symptoms are treated with physical (physiotherapy, massage) or pharmacologic (NSAID, opioid) interventions, with surgery restricted to debilitating degenerative disease that is non-refractory to conservative management. While these treatments may reduce pain in some cases, they do not address the pathologic mechanisms of disease and outcomes are often tenuous. The co-branded ISSLS-ORS symposium will present, 1) the latest development of accurate and specific markers to detect and follow disease; 2) how pharmacological and non-pharmacological treatment methods can be evaluated in preclinical animal models; and 3) current clinical phenotyping and treatment options.

Working in partnership with the ORS ad hoc Education Committee and the ORS Spine Section, the results/expected outcomes of this symposium will be multifaceted. For example, we anticipate an understanding and increased awareness of the aforementioned, cross – multi-discipline discussions, collaborations, innovation, promotion of new research lines etc. In addition, the symposium will be video recorded and made available on the ISSLS website for educational purposes. A potential article of the symposium will be drafted for journal publication. Members from both the ISSLS ad hoc Education Committee and the ORS Spine Section may develop special theme/focus issues with a peer-reviewed journal (e.g. European Spine Journal, JOR-Spine, Global Spine Journal, SPINE, etc) on the aforementioned low back pain topic.

Speakers:

Lars Arendt-Nilsen, MD, PhD
Aalborg University Hospital
Denmark

Laura Stone, PhD
Department of Anesthesiology
University of Minnesota, USA

Jaro Karppinen, MD, PhD
Oulu University
Finland

Following each group of three speakers, there will be a 15-minute discussion in this session.

• Immediate postoperative decrease in Hounsfield unit values at adjacent vertebral levels after long thoracolumbar fusion with pelvic fixation as a risk factor of proximal junctional kyphosis. - Koki Tsuchiya
• Is spinal osteotomy associated with decreased life expectancy? - A nationwide population-based study - Jae-Won Shin
• The Ontario rapid access clinics – low back pain (RAC-LBP) interprofessional assessment and education program: Pilot to full-scale success story  - Y. Raja Rampersaud
• CHRONIC LOW BACK PAIN (CLBP) CAUSAL RISK FACTORS: A PRELIMINARY ANALYSIS OF THE BACKHOME COHORT - Conor ONeill
• A PROSPECTIVE LONGITUDINAL STUDY TO IDENTIFY THE MODIFIABLE DETERMINANTS OF WALKING IN OLDER ADULTS AFTER SURGERY FOR NEUROGENIC CLAUDICATION - Suzanne McIlroy
• EXPLORING THE EFFICACY, FEASIBILITY AND OPTIMAL TRAINING PARAMETERS FOR RUNNING IN ADULTS WITH NON-SPECIFIC CHRONIC LOW BACK PAIN: THE ASTEROID RANDOMISED CONTROLLED TRIAL - Christopher Neason

Following each group of three speakers, there will be a 15-minute discussion in this session.

• Discovery of Circulating Blood Biomarkers in Patients With and Without Lumbar Modic Changes - Jaro Karppinen
• Magnetic resonance spectroscopy biomarker of Modic changes with bacterial etiology   - Aaron J Fields
• PARASPINAL MUSCLE FIBRE STRUCTURAL AND CONTRACTILE CHARACTERISTICS DEMONSTRATE DISTINCT IRREGULARITIES IN SPINAL DEGENERATION AND DEFORMITY PATIENTS - Stephen H.M. Brown
• HOW IS LUMBAR INTRADISCAL PRESSURE AFFECTED BY DISC DEGENERATION, AGE, SEX, AND LEVEL? EVALUATION OF AN IN VITRO DATABASE COMPRISING 107 HUMAN SPECIMENS   - Christian Liebsch
• Epigenetic Regulation of IL-4 Promoter Targeting p300 Attenuating Intervertebral Disc Degeneration and Pain by Inhibiting IL-1β - Haowen Cui
• Increased HTRA1 Generated Fragment Abundance in the Degradome of Modic Type 1 Discs - Tamara Mengis

Following each group of three speakers, there will be a 15-minute discussion in this session.

• USING MACHINE LEARNING TO PREDICT THE LIKELIHOOD OF SUCCESS AFTER LUMBAR FUSION - Paul Licina
• Surgical Site Infections Following Posterior Lumbar Fusion - Kasra Araghi
• Effectiveness and Safety of OLIF51 Based on Pre-Registry Data from Proctor Facilities in Japan - Sumihisa Orita
• Hip osteoarthritis after spinal fusion surgery: a 5-year follow-up study - Takuhei TK Kozaki
• ANTERIOR LUMBAR INTERBODY FUSION FOR THE TREATMENT OF FAILED TRANSFORAMINAL LUMBAR INTERBODY FUSION - Donna D Ohnmeiss

Foundation of ISSLS: Gunnar Andersson

Evolution of ISSLS perspectives:
   Jiri Dvorak - Europe 
   James Kang - North America
   Peter Robertson - Australia, HK, Singapore, India
   Seiji Ohtori - Japan, Korea, China